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Welcome to RosettaBackrub
This is the flexible backbone protein structure modeling and design server of the Kortemme Lab. The server utilizes the "backrub" method, first described by Davis et al.1, for flexible protein backbone modeling implemented in Rosetta2,3,5,6,7.
The server input is a protein structure (a single protein or a protein-protein complex) in PDB format uploaded by the user or obtained directly from the PDB plus some application-specific parameters. The server output is dependent on the application:
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For questions, please read our documentation, see the references below, or contact .
 Davis IW, Arendall III WB, Richardson DC, Richardson JS. The Backrub Motion: How Protein Backbone Shrugs When a Sidechain Dances.
 Friedland GD, Lakomek NA, Griesinger C, Meiler J, Kortemme T. A Correspondence between Solution-State Dynamics of an Individual Protein and the Sequence and Conformational Diversity of its Family.
 Humphris EL, Kortemme T. Prediction of Protein-Protein Interface Sequence Diversity using Flexible Backbone Computational Protein Design.
 Lauck F, Smith CA, Friedland GD, Humphris EL, Kortemme T. RosettaBackrub - A web server for flexible backbone protein structure modeling and design.
 Smith CA, Kortemme T. Backrub-Like Backbone Simulation Recapitulates Natural Protein Conformational Variability and Improves Mutant Side-Chain Prediction.
 Smith CA, Kortemme T. Structure-Based Prediction of the Peptide Sequence Space Recognized by Natural and Synthetic PDZ Domains.
 Smith CA, Kortemme T. Predicting the Tolerated Sequences for Proteins and Protein Interfaces Using Rosetta Backrub Flexible Backbone Design.